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KMID : 0043320120350030455
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Archives of Pharmacal Research
2012 Volume.35 No. 3 p.455 ~ p.460
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Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues: Insight into their structure-activity relationships
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Lee Su-Jin
Marharjan Sony
Jung Jong-Wha
Kim Nam-Jung
Kim Kyeo-Jin
Han Young-Taek
Lim Chang-Jin
Choi Hyun-Jung
Kwon Young-Geun
Suh Young-Ger
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Abstract
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Design, synthesis and insight into the structure-activity relationships (SAR) of phytosterol analogues as novel antiapoptotic agents are described. In particular, the non-branched alkyl chain at C24 and the pseudosugar moiety at C3 hydroxyl group turned out crucial for the inhibition of human umbilical vein endothelial cells (HUVEC) apoptosis.
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KEYWORD
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Antiapoptotic agent, Phytosterol, HUVEC
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